Calciumgaben bei Osteoporose – mehr Schaden als Nutzen?

Autor: Andreas Hahn, Alexander Ströhle


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  18. Kanis JA, McCloskey EV, Johansson H, Cooper C, Rizzoli R, Reginster JY; Scientific Advisory Board of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) and the Committee of Scientific Advisors of the International Osteoporosis Foundation (IOF). European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int. 2013 Jan;24(1):23-57.
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  29. Ströhle A, Hahn A. Nährstoffsupplemente - Möglichkeiten und Grenzen. Teil 5: Supplemente in der Primärprävention - Methodologische Aspekte, Med Monatsschrift Pharm 2014a; 37 (1):13-26.
  30. Ströhle A, Hahn A. Nährstoffsupplemente - Möglichkeiten und Grenzen. Teil 6: Sicherheit und mögliche Risiken, Med Monatsschr Pharm. 2014b; 37 (7): 249-256.
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Differenzierte Evidenz für Wirksamkeit und Sicherheit von Traubensilberkerze zur Behandlung klimakterischer Beschwerden

Autor: André-Michael Beer


  1. EMA European Medicine Agency. Committee on Herbal Medicinal Products (HMPC). Community herbal monograph on Cimicifuga racemosa (L.) Nutt., rhizome. EMA/HMPC/600717/2007 Corr., first published 20/01/2011, last updated 26/04/2011.
  2. Leach MJ, Moore V. Black cohosh (Cimicifuga spp.) for menopausal symptoms. Cochrane Database Syst Rev 2012;Sep 12;9:CD007244. doi: 10.1002/14651858.CD007244.pub2.
  3. Beer A-M, Osmers R, Schnitker J, Bai W, Mueck AO, Meden H. Efficacy of black cohosh (Cimicifuga racemosa) medicines for treatment of menopausal symptoms – comments on major statements of the Cochrane Collaboration report 2012 "black cohosh (Cimicifuga spp.) for menopausal symptoms /review)". Gynecol Endocrinol 2013;29(12):1022-5.
  4. Beer A-M, Neff A. Differentiated evaluation of extract-specific evidence on Cimicifuga racemosa's efficacy and safety for climacteric complaints. Evid based Complement Alternat med 2013; Article ID 860602,
  5. Osmers R, Friede M, Liske E, Schnitker J, Freudenstein J, Henneicke-von Zepelin H-H. Efficacy and safety of isopropanolic black cohosh extract for climacteric symptoms. Obstet Gynecol 2005;105:1074-83.
  6. Bai W, Henneicke-von Zepelin HH, Wang S, Zheng S, Liu J, Zhang Z, Geng L, Hu L, Jiao C, Liske E. Efficacy and tolerability of a medicinal product containing an isopropanolic black cohosh extract in Chinese women with menopausal symptoms: a randomized, double blind, parallel-controlled study versus tibolone. Maturitas 2007;58:31-41.
  7. Nappi RE, Malavasi B, Brundu B, Facchinetti F. Efficacy of Cimicifuga racemosa on climacteric complaints: a randomized study versus low-dose transdermal estradiol. Gynecol Endocrinol 2005;20(1):30-5.
  8. Uebelhack R, Blohmer JU, Graubaum HJ, Busch R, Gruenwald J, Wernecke KD. Black cohosh and St. John's wort for climacteric complaints: a randomized trial. Obstet Gynecol 2006;107:247-55.
  9. Liske E, Hänggi W, Henneicke-von Zepelin HH, Boblitz N, Wüstenberg P. Rahlfs VW. Physiological investigation of a unique extract of black cohosh (Cimicifugae racemosae rhizoma): a 6-month clinical study demonstrates no systemic estrogenic effect. J Womens Health Gend Based Med 2002;11(2):163-74.
  10. Briese V, Stammwitz U, Friede M, Henneicke-von Zepelin HH. Black cohosh with or without St. John's wort for symptom-specific climacteric treatment - results of a large-scale, controlled, observational study. Maturitas 2007;57:405-14.
  11. Schmidt M, Polasek W, Käufeler R. Wirksamkeit und Sicherheit von Traubensilberkerze (Cimicifuga racemosa, Cimifemin®) bei Menopausebeschwerden: Therapiebeobachtung unter Praxisbedingungen. J Menopause 2005;12(1):30-4.
  12. Vermes G, Banhidy F, Acs N. The Effects of Remifemin® on Subjective Symptoms of Menopause. Adv Ther 2005;22(2):148-54.
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  14. Wuttke W, Seidlová-Wuttke D, Gorkow C. The Cimicifuga preparation BNO 1055 vs. conjugated estrogens in a double-blind placebo-controlled study: effects on menopause symptoms and bone markers. Maturitas 2003;44(Suppl.l):67-77.
  15. Wuttke W, Raus K, Gorkow C. Efficacy and tolerability of the Black cohosh (Actaea racemosa) ethanolic extract BNO 1055 on climacteric complaints: A double-blind, placebo- and conjugated estrogens-controlled study. Maturitas 2006;55:83-91.
  16. Raus K, Brucker C, Gorkow C, Wuttke W. First-time proof of endometrial safety of the special black cohosh extract (Actaea or Cimicifuga racemosa extract) CR BNO 1055. Menopause 2006;13(4):678-91.
  17. Frei-Kleiner S, Schaffner W, Rahlfs VW, Bodmer Ch, Birkhäuser M. Cimicifuga racemosa dried ethanolic extract in menopausal disorders: a double-blind placebo-controlled clinical trial. Maturitas 2005;51:397-404.
  18. Oktem M, Eroglu D, Karahan HB, Taskintuna N, Kuscu E, Zeyneloglu HB. Black cohosh and fluoxetine in the treatment of postmenopausal symptoms: a prospective, randomized trial. Adv Ther 2007;24(2):448-61.
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  21. Newton KM, Reed SD, LaCroix AZ, Grothaus LC, Ehrlich K, Guiltinan J. Treatment of vasomotor symptoms of menopause with black cohosh, multibotanicals, soy, hormone therapy, or placebo: a randomized trial. Ann Intern Med 2006;145(12):869-79.
  22. Geller SE, Shulman LP, van Breemen RB, Banuvar S, Zhou Y, Epstein G, Hedayat S, Nikolic D, Krause EC, Piersen CE, Bolton JL, Pauli GF, Farnsworth NR. Safety and efficacy of black cohosh and red clover for the management of vasomotor symptoms: a randomized controlled trial. Menopause 2009;16(6):1156-66.
  23. Ruhlen RL, Haubner J, Tracy JK, Zhu W, Ehya H, Lamberson WR, Rottinghaus GE, Sauter ER. Black cohosh does not exert an estrogenic effect on the breast. Nutr Cancer 2007;59(2):269-77.
  24. Naser B, Schnitker J, Minkin MJ, de Arriba SG, Nolte KU, Osmers R. Suspected black cohosh hepatotoxicity: no evidence by meta-analysis of randomised controlled clinical trials for isopropanolic black cohosh extract. Menopause 2011;18(4):366-75.
  25. Jacobson JS, Troxel AB, Evans J, Klaus L, Vahdat L, Kinne D, Lo KM, Moore A, Rosenman PJ, Kaufman EL, Neugut AI, Grann VR. Randomized Trial of Black Cohosh for the Treatment of Hot Flashes Among Women With a History of Breast Cancer. J Clin Oncol 2001;19(10):2739-45.
  26. Garcia-Perez MA, Pineda B, Hermenegildo C, Tarín JJ, Cano A. Isopropanolic Cimicifuga racemosa is favorable on bone markers but neutral on an osteoblastic cell line. Fertil Steril 2009;91(4,Suppl):1347-50.
  27. Pockaj BA, Loprinzi CL, Sloan JA, Novotny PJ, Barton DL, Hagenmaier A, Zhang H, Lambert GH, Reeser KA, Wisbey JA. Pilot evaluation of black cohosh for the treatment of hot flashes in women. Cancer Invest 2004;22(4):515-21.
  28. Lindén-Hirschberg A, Edlund M, Svane G, Azavedo E, Skoog L, von Schoultz B. An isopropanolic extract of black cohosh does not increase mammographic breast density or breast cell proliferation in postmenopausal women. Menopause 2007;14(1):89-96.
  29. Reame NE, Lukacs JL, Padmanabhan V, Eyvazzadeh AD, Smith YR, Zubieta JK. Black cohosh has central opiod activity in postmenopausal women: evidence from naloxone blockade and positron emission tomography neuroimaging. Menopause 2008;15(5):832-40.
  30. Rostock M, Fischer J, Mumm A, Stammwitz U, Saller R, Bartsch HH. Black cohosh (Cimicifuga racemosa) in tamoxifen-treated breast cancer patients with climacteric complaints – a prospective observational study. Gynecol Endocrinol 2011;27(10):844-8.
  31. Lundström E, Hirschberg AL, Söderqvist G. Digitized assessment of mammographic breast density. Effects of continuous combined hormone therapy, tibolone and black cohosh compared to placebo. Maturitas 2011;70(4):361-4.
  32. Rebbeck TR, Troxel AB, Norman S, Bunin GR, DeMichele A, Baumgarten M, Berlin M, Schinnar R, Strom BL. A retrospective case-control study of the use of hormone-related supplements and association with breast cancer. Int J Cancer 2007;120:1523-8.
  33. Obi N, Chang-Claude J, Berger J, Braendle W, Slanger T, Schmidt M, Steindorf K, Ahrens W, Flesch-Janys D. The use of herbal preparations to alleviate climacteric disorders and risk of postmenopausal breast cancer in a German case-control study. Cancer Epidemiol Biomarkers Prev 2009;18(8):2207-13.
  34. Henneicke-von Zepelin HH, Meden H, Kostev K, Schröder-Bernhardi D, Stammwitz U, Becher H. Isopropanolic black cohosh extract and recurrence-free survival after breast cancer. Intern J Clin Pharmacol Ther 2007;45(3):143-54.
  35. Hernández-Munoz G, Pluchino S. Cimicifuga racemosa for the treatment of hot flushes in women surviving breast cancer. Maturitas 2003;44 (Suppl I):59-65.
  36. Nasr A, Nafeh H. Influence of black cohosh (Cimicifuga racemosa) use by postmenopausal women on total hepatic perfusion and liver functions. Fertil Steril 2009;92(5):1780-2.
  37. Reed SD, Newton KM, LaCroix AZ, Grothaus LC, Grieco VS, Ehrlich K. Vaginal, endometrial, and reproductive hormone findings: randomized, placebo-controlled trial of black cohosh, multibotanical herbs, and dietary soy for vasomotor symptoms: the Herbal Alternatives for Menopause (HALT) Study. Menopause 2008;15(1):51-8.
  38. Brasky TM, Lampe JW, Potter JD, Patterson RE, White E. Speciality Supplements and Breast Cancer Risk in the VITamins And Lifestyle (VITAL) Cohort. Cancer Epidemiol Biomarkers Prev 2010;19(7):1696-708.
  39. Firenzuoli F, Gori L, Roberti di Sarsina P. Black Cohosh Hepatic Safety: Follow-Up of 107 Patients Consuming a Special Cimicifuga racemosa rhizome Herbal Extract and Review of Literature. Evid Based Complement Alternat Med 2011;821392. doi:10.1093/ecam/nen009.

Phytopharmaka bei Wechseljahrsbeschwerden

Autor: André-Michael Beer


  1. Beer AM, Adler M (eds). Leitfaden für Naturheilverfahren für die ärztliche Praxis. München: Elsevier, 2011, 1. Aufl. 
  2. Schilcher H; Loew D (2013).  Phytopharmaka als Alternative zu Synthetika. MMW-Fortschr Med,Originalien IV 155 (4): 97-99
  3. EMA European Medicine Agency. Committee on Herbal Medicinal Products (HMPC). Community herbal monograph on Cimicifuga racemosa (L.) Nutt., rhizome. EMA/HMPC/600717/2007 Corr., first published 20/01/2011, last updated 26/04/2011.
  4. Beer A-M, Neff A. Differentiated evaluation of extract-specific evidence on Cimicifuga racemosa's efficacy and safety for climacteric complaints. Evid based Complement Alternat med 2013; Article ID 860602,
  5. Leach MJ, Moore V. Black cohosh (Cimicifuga spp.) for menopausal symptoms.Cochrane Database Syst Rev 2012;Sep 12;9:CD007244. doi: 10.1002/14651858.CD007244.pub2.
  6. Beer A-M, Osmers R, Schnitker J, Bai W, Mueck AO, Meden H. Efficacy of black cohosh (Cimicifuga racemosa) medicines for treatment of menopausal symptoms – comments on major statements of the Cochrane Collaboration report 2012 "black cohosh (Cimicifuga spp.) for menopausal symptoms /review)". Gynecol Endocrinol 2013;29(12):1022-5. 
  7. Beer AM. Cimicifuga racemosa bei klimaterischen Beschwerden. Aktuelle Daten bestätigen Wirksamkeit und Sicherheit. Z Phytotherapie 2015;36: 10-17
  8. Stute P, Pickartz S. Zusatznutzen eines isopropanolischen Cimicifuga-racemosa-Extraktes (iCR). Positive Beeinflussung von Knochenstoffwechsel und –qualität. Z Phytotherapie 2015; 36: 18–22 
  9. Seidlová-Wuttke D. Schützt Cimicifuga-Spezialextrakt vor Osterporose? NaturaMed 2009 1 (24)
  10. Liske E, Henneicke-von Zepelin HH, Pickartz S, Meden H. Wirkung des isopropanolischen Cimicifuga-racemosa-Extrakts iCR auf Uterusmyome bei Frauen mit klimakterischen Beschwerden. Z Phytotherapie 2015; 36: 23–26
  11. Xi S, Liske E, Wang S et al. Effect of isopropanolic Cimicifuga racemosa extract on uterine fibroids in comparison with Tibolone among patients of a recent randomized, double blind, parallel-controlled study in Chinese women with menopausal symptoms. Evid Based Complement Altern Med. 2014;2014:717686
  12. Beer AM (2014). Traubensilberkerze und Rapontikrhabarber bei klimakterischen Beschwerden. Evidenz spricht für die Phytotherapie. MMW-Fortschr Med, 156 (8): 40-41
  13. Beer AM. Vitex agnus-castus: Evidenzbasierte Therapie bei zyklusabhängigen Beschwerden. Z Phytotherapie 2015; 36: 4–9
  14. Kommission E. Monographie Agni casti fructus (Keuschlammfrüchte). BAnz 1992; 226
  15. European Medicines Agency, Committee on Herbal Medicinal Products (HMPC) Assessment report on Vitex agnus-castus L., fructus, 2011.25 November 2010 EMA/HMPC/144003/2009
  16. Deutsche Pharmazeutische Gesellschaft e.V.: Gute Substitutionspraxis. Leitlinie, Stand: 24.2.2014

Behandlung akuter Vulvovaginalmykosen mit Clotrimazol

Autoren: Hans-Jürgen Tietz, Ingo Stock, Morbert Becker


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  3. Mendling W. Vaginitis, Zervizitis und Salpingitis. Springer Medizin Verlag, 2. Auflage. Heidelberg 2006.  
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  6. Romeo O, Tietz H-J, Criseo G. Candida africana: is it a fungal pathogen? Curr Fungal Infect Rep 2013;7:192–7.
  7. Stock I. Pilzerkrankungen der Vulva und Vagina durch Candida-Arten. Erreger, Krankheitsbilder und Behandlungsoptionen. Med Monatsschr Pharm 2010;33:324–33.
  8. Tietz H-J. Behandlung akuter Vaginalmykosen mit Clotrimazol. Vergleich der topischen Ein- und Dreitagekombinationstherapie. gyne 2011;11:12–5.
  9. Tietz H-J. Mykosen in der Gynäkologie. Frauenarzt 2014;55:28–33.
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  11. Tietz H-J, Becker N. Akute Vaginalmykose. Vergleichende Untersuchung der 1- und 3-Tage-Therapie mit Clotrimazol. Pharm Zeitung 2009;154:1437–42.

Seniorin mit Brustkrebs will keine OP – was tun?

Autor: J.M. Wenderlein


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